diffuse large B-cell lymphomas with non-germinal center B-cell phenotype
Thursday 4 July 2013
Definition: Diffuse large B-cell lymphomas (DLBCL) with low/absent CD20/CD79a and an immunophenotype indicative of terminal B-cell differentiation (MUM1/CD38/CD138/EMA-positive).
Gene expression profiling studies of diffuse large B-cell lymphoma have identified two major subtypes, those with an expression pattern similar to normal germinal center B-cells and those similar to the activated peripheral blood cells, with the former carrying a significantly better prognosis after chemotherapy.
Using immunohistochemistry (CD10, bcl-6, and IRF4/MUM-1), Hans et al. classified diffuse large B-cell lymphomas into germinal center B-cell vs non-germinal center B-cell phenotype and found a good concordance with gene expressing profiling and a better prognosis in the group with germinal center B-cell phenotype than that with non-germinal center B-cell phenotype, a similar finding to the gene expression profiling studies.
Most primary adrenal lymphomas are diffuse large B-cell lymphomas with non-germinal center B-cell phenotype, BCL6 gene rearrangement and poor prognosis. Mozos A, Ye H, Chuang WY, Chu JS, Huang WT, Chen HK, Hsu YH, Bacon CM, Du MQ, Campo E, Chuang SS. Mod Pathol. 2009 Sep;22(9):1210-7. doi:10.1038/modpathol.2009.87 . PMID: #19525926# [Free]
Differences in germinal centre and non-germinal center phenotype in gastric and intestinal diffuse large B-cell lymphomas. Mitchell KA, Finn WG, Owens SR. Leuk Lymphoma. 2008 Sep;49(9):1717-23. doi:10.1080/10428190802238552 . PMID: #18798105#