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diffuse large B cell lymphomas with a germinal center phenotype

Thursday 4 July 2013

diffuse large B cell lymphomas with a germinal center immunophenotype (GCB-DLBCL)

Studies with cDNA microarrays showed that diffuse large B-cell lymphoma (DLBCL) cases with gene expression profiles similar to germinal center (GC) B cells had much better prognosis than DLBCL cases with gene expression profiles resembling activated B cells.

Expression patterns of panel of GC B-cell and activation markers by immunohistochemistry correlate with the prognosis of patients with DLBCL.

Immunohistochemical analysis on paraffin-embedded tissues is more readily available than gene expression profiling by cDNA microarray and may provide similar prognostic information.

References

- Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Chang CC, McClintock S, Cleveland RP, Trzpuc T, Vesole DH, Logan B, Kajdacsy-Balla A, Perkins SL. Am J Surg Pathol. 2004 Apr;28(4):464-70. PMID: 15087665