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Histologic transformation of low-grade B-cell...

Thursday 4 July 2013

Histologic transformation of low-grade B-cell lymphoma to diffuse large B-cell lymphoma is associated with poor prognosis. Although plasma cell differentiation is common in these lymphomas, an overt plasmablastic transformation (PBL-T) is only rarely reported.

PBL-T expands the clinicopathologic spectrum of the transformation of low-grade B-cell lymphomas.

These transformed tumors are clinically, histologically, and phenotypically similar to primary plasmablastic lymphomas, but they are not associated with immunodeficiency and rarely have Epstein-Barr virus infection or MYC alterations.

References

- Plasmablastic transformation of low-grade B-cell lymphomas: report on 6 cases. Martinez D, Valera A, Perez NS, Sua Villegas LF, Gonzalez-Farre B, Sole C, Gine E, Lopez-Guillermo A, Roue G, Martinez S, Sant F, Warzocha K, Robak T, Czader M, Villamor N, Colomo L, Campo E, Martinez A. Am J Surg Pathol. 2013 Feb;37(2):272-81. doi : 10.1097/PAS.0b013e31826cb1d1 PMID: 23282972