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KRAS-G12C

COSM516

Monday 1 July 2013

p.Gly12Cys c.34G>T

COSMIC

- http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=516
- http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1140136
- http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=25878
- http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=513

The G12C KRAS mutation is a strong negative predictor for EGFR-TKI treatment, whereas other KRAS mutation types have not negatively predicted treatment efficacy compared with that for the wild-type KRAS genotype. (23313110)

References

- The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Fiala O, Pesek M, Finek J, Benesova L, Belsanova B, Minarik M. Cancer Genet. 2013 Jan-Feb;206(1-2):26-31. doi : 10.1016/j.cancergen.2012.12.003 PMID: 23313110