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EGFR-G719X

Friday 28 June 2013

’Classical’ mutations in the EGFR tyrosine kinase domain (exons 18, 19 and 21) have been associated with sensitivity to tyrosine kinase inhibitors (TKIs) in patients with NSCLC.

These classical mutations are : G719X, DEL19 and L858R mutations and confer sensitivity to TKIs.