congenital CMV infection
Wednesday 26 June 2013
Congenital cytomegalovirus (CMV) infection may be asymptomatic until hearing loss manifests in childhood.
PCR diagnosis from FFPE
Because diagnosis of congenital CMV requires viral detection within an infant’s first 21 days of life, CMV polymerase chain reaction (PCR) on formalin-fixed, paraffin-embedded (FFPE) placental tissue provides a unique opportunity to identify congenital exposure in cases in which CMV is not initially suspected.
The confirmation of CMV exposure in utero by PCR of FFPE placental tissue provides a useful adjunct to histologic evaluation and may identify infants requiring close clinical follow-up.
Diagnosis of Congenital CMV Using PCR Performed on Formalin-fixed, Paraffin-embedded Placental Tissue.
Folkins AK, Chisholm KM, Guo FP, McDowell M, Aziz N, Pinsky BA. Am J Surg Pathol. 2013 Jun 20. PMID: 23797721