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SDH-associated vesical paraganglioma - Humpath.com - Human pathology

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SDH-associated vesical paraganglioma

Wednesday 26 June 2013

SDH-deficient Bladder Paragangliomas

Molecular variants

- Succinate Dehydrogenase-deficient Bladder Paragangliomas (23797725)

  • A significant subset of bladder paragangliomas is SDH deficient.
  • It is essential to identify SDH-deficient tumors, as the presence of an SDH mutation has prognostic implications and is important in guiding genetic counseling.

References

- Identification of Succinate Dehydrogenase-deficient Bladder Paragangliomas. Mason EF, Sadow PM, Wagner AJ, Remillard SP, Flood TA, Belanger EC, Hornick JL, Barletta JA. Am J Surg Pathol. 2013 Jun 20. PMID: 23797725