succinate dehydrogenase-deficient paraganglioma
Wednesday 26 June 2013
Tumors with mutations in SDH genes can be identified using immunohistochemistry.
Loss of SDHB staining is seen in tumors with a mutation in any one of the SDH genes, whereas loss of both SDHB and SDHA expression is seen only in the context of an SDHA mutation.
Identifying an SDH-deficient tumor can be prognostically significant, as tumors with SDHB mutations are more likely to pursue a malignant course.
Although the rate of SDH deficiency in paragangliomas in general is known to be approximately 30%.
Identification of Succinate Dehydrogenase-deficient Bladder Paragangliomas. Mason EF, Sadow PM, Wagner AJ, Remillard SP, Flood TA, Belanger EC, Hornick JL, Barletta JA. Am J Surg Pathol. 2013 Jun 20. PMID: 23797725