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Home > A. Molecular pathology > Variants-Mutants > EGFR-L858R


Tuesday 25 June 2013

EGFR c.2573T>G


Patients with lung cancer who respond to gefitinib have been reported to have somatic mutations consisting of deletions in exon 19 and the L858R mutation in exon 21 of the epidermal growth factor receptor (EGFR) gene.

Lung cancers harboring the EGFR L858R mutation have been reported to be responsive to gefitinib.

The studies of cells expressing L858R revealed increased gefitinib sensitivity in vitro.


- A patient with gefitinib-resistant lung adenocarcinoma harboring both T790M and L858R at diagnosis has also been described.

  • In addition, a second mutation (T790M) in exon 20 is also associated with acquired resistance to gefitinib in initially gefitinib-sensitive patients.


- 43B2 Rabbit mAb - EGF Receptor (L858R Mutant Specific) (43B2).
- SP125 - Anti-EGFR L858R (SP125) Rabbit Monoclonal Primary Antibody

Open references

- Comparing overall survival between first generation EGFR-TKIs and chemotherapy in lung cancer patients with Del19/L858R.
Deng W, Lei Y, Liu S, Yang J, Tu H, Yan H, Wu Y. Chin J Cancer Res. 2016 Jun;28(3):339-47. doi : 10.21147/j.issn.1000-9604.2016.03.08 PMID: 27478319 Free