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metatypical basal cell carcinoma

Wednesday 22 May 2013

Metatypical type

Although the term ’metatypical’ is sometimes applied to tumors with mixed basaloid and squamous features, it should be reserved for the rare basal cell carcinoma composed of nests and strands of cells maturing into larger and paler cells.

Peripheral palisading is often lost.

The cells express much less keratin 17 and keratin 8 than do the cells in the more usual types of basal cell carcinoma.

Peripheral palisading is less obvious than usual, and the stroma is often prominent.

This variant is regarded by some as having metastatic potential.