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splenic amyloidosis

Sunday 19 May 2013

spleen amyloidosis

PO

Synopsis

Macroscopy

- firm consistency
- waxy consistency
- possible sago spleen
- possible lardaceous spleen
- splenomegaly
- diffuse splenic infiltration
- possible localized splenic nodules
- rare splenic rupture

Microscopy

- splenic deposition of pink amorphous material

  • deposition of pink amorphous material limited either to germinal follicles (sago spleen)
  • deposition of pink amorphous material along splenic sinusoids
  • deposition of pink amorphous material in surrounding connective tissue (lardaceous spleen)

- splenic deposition of amyloid (amyloidosis)

  • deposition of amyloid limited either to germinal follicles (sago spleen)
  • deposition of amyloid along splenic sinusoids
  • deposition of amyloid in surrounding connective tissue (lardaceous spleen)

Etiology

- amyloidosis

  • mostly secondary amyloidosis
  • rare primary amyloidosis

See also

- splenic diseases
- amyloidosis