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spleen in hemolytic anemia

Saturday 18 May 2013

Types of hemolytic anemia

- congenital hemolytic anemia

  • hereditary spherocytosis
  • sickle cell anemia

- acquired hemolytic anemia

  • deposition of immune complexes on red blood cell membranes
  • bacterial hemolysins
  • plasma lipid abnormalities
  • parasites

- immune hemolytic anemia

  • brucellosis
  • Hodgkin lymphoma
  • leukemia
  • sarcoidosis
  • SLE (lupus)
  • tuberculosis

Microscopy

- splenic congestion in cords and sinuses
- splenic hemosiderin deposition
- splenicextramedullary hematopoiesis
- splenicerythrophagocytosis with neutrophils
- splenic reactive follicular hyperplasia