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YWHAE-associated endometrial stromal sarcoma

Tuesday 14 May 2013

Pathology

- YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas (#23599159#)

  • Endometrial stromal sarcomas represent the second most common mesenchymal uterine tumor.
  • The 2003 WHO classification distinguishes low-grade and undifferentiated endometrial stromal sarcomas with different prognoses.
  • Endometrial stromal sarcomas are a genetically heterogeneous group of sarcomas harboring different cytogenetic anomalies.
  • A fusion between the YWHAE and FAM22A/B genes subsequent to a t(10;17) (q22;p13) has been described in endometrial sarcomas with high-grade histology.

References

- YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations. Croce S, Hostein I, Ribeiro A, Garbay D, Velasco V, Stoeckle E, Guyon F, Floquet A, Neuville A, Coindre JM, Macgrogan G, Chibon F. Mod Pathol. 2013 Apr 19. doi: 10.1038/modpathol.2013.69 . PMID: #23599159#