Home > E. Pathology by systems > Digestive system > Colon and rectum > multinucleate epithelial change in colorectal hyperplastic polyp

multinucleate epithelial change in colorectal hyperplastic polyp

Tuesday 30 April 2013

Multinucleate epithelial change in colorectal hyperplastic polyps

Hyperplastic polyps containing multinucleated epithelial giant cells (MEGs) show active inflammation and apoptosis, and in most there was also focal inflammation and apoptosis in the adjacent mucosa.

Inflammation in conjunction with the increased epithelial proliferation characteristics of hyperplastic polyps could be the mechanism for the MEG formation.

References

- Multinucleate epithelial change in colorectal hyperplastic polyps: a review of 27 cases. Lambie DL, Brown IS. J Clin Pathol. 2008 May;61(5):611-4. PMID: #18037663#

- Multinucleated epithelial giant cells in colorectal polyps: a potential mimic of viropathic and/or dysplastic changes. Kambham N, Troxell M, Longacre TA. Am J Surg Pathol. 2005 Jul;29(7):912-9. PMID: #15958856#