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high-grade dysplasia in Barrett esophagus

Tuesday 16 April 2013

Barrett Esophagus : High-grade Dysplasia

Images

- High grade dysplasia in Barrett esophagus

- High grade dysplasia in Barrett esophagus with strong nuclear TP53 immunolabeling

Dysplasia in Barrett esophagus is dividied into low-grade and high-grade. Dysplastic changes are most often seen in the areas of incomplete intestinal metaplasia.

In high-grade dysplasia, he glands are crowded and irregularly shaped and there is nuclear hyperchromasia, increased mitotic activity, and prominent nucleoli.