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low-grade dysplasia in Barrett esophagus

Tuesday 16 April 2013

Barrett Esophagus : Low-grade Dysplasia

Images

- http://www.webpathology.com/image.asp?case=185&n=5

Barrett esophagus is a pre-malignant condition. It is important to look for dysplasia when Barrett esophagus is diagnosed. Dysplastic changes consist of both cytologic as well as architectural atypia.

Cytologic changes include nuclear hyperchromasia and stratification, irregularly clumped chromatin, increased N:C ratios, increased mitotic activity including abnormal mitotic figures, and loss of polarity.