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myxoid tumors of soft tissue

Wednesday 10 April 2013

myxoid tumors of soft tissues; myxoid lesions of soft tissue; soft tissue myxoid tumors

Digital cases

- Circumscribed myxoid lesion of finger by Ed Euthman

Myxoid tumours of soft tissue encompass a heterogeneous group of lesions characterized by a marked abundance of extracellular mucoid (myxoid) matrix. This group of tumours demonstrate significant variability in their biological behaviour thus including tumours which are entirely harmless, tumours with a tendency to recur locally but not metastasize, and malignant tumours.

There appears to be a considerable degree of overlap clinically and morphologically between the various tumour types in this group, generating potential diagnostic problems for the clinician and pathologist alike.

While diligent microscopy remains the basis of diagnostic pathology, the continuous developments and refinements within the fields of immunohistochemistry and molecular cytogenetics are providing substantial new information, allowing the development of new diagnostic criteria and hence facilitating an accurate diagnosis.

Benign Locally aggressive Malignant
Dermal myxoma Juxta-articular myxoma Myxofibrosarcoma
Superficial angiomyxoma Aggressive angiomyxoma Low-grade fibromyxoid sarcoma
Ganglion (Low-grade myxofibrosarcoma) Myxoid liposarcoma
Myxoid nodular fasciitis (Atypical OFMT) Extraskeletal myxoid chondrosarcoma
Myxoid neurofibroma Myxoid leiomyosarcoma
Myxolipoma Myxoid MPNST
Dermal nerve sheath myxoma Myxoid DFSP
Intramuscular myxoma Myxopapillary ependymoma
Ossifying fibromyxoid tumour (OFMT)

Links

- http://www.pathologydiagnostics.org/userfiles/Myxoid_tumours.pdf

References

- Myxoid tumours of soft tissue. Graadt van Roggen JF, Hogendoorn PC, Fletcher CD. Histopathology. 1999 Oct;35(4):291-312. PMID: 10564384 http://www.pathologydiagnostics.org/userfiles/Myxoid_tumours.pdf