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ROS1

Friday 15 March 2013

WP

Pathology

- ROS1 rearrangement in lung adenocarcinoma

- ROS1 rearrangement in gastric adenocarcinoma.(23400546)

  • ROS1-rearranged lung adenocarcinoma

- PDGFRB-ROS1 gene fusion between ROS1 and PDGFRB in :

Targeted therapy

- ROS1 inhibitors

Open references

- Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement.
Antonescu CR, Suurmeijer AJ, Zhang L, Sung YS, Jungbluth AA, Travis WD, Al-Ahmadie H, Fletcher CD, Alaggio R. Am J Surg Pathol. 2015 Jul;39(7):957-67. doi : 10.1097/PAS.0000000000000404
PMID: 25723109 Free

Paywall References

- ROS1-Rearranged Lung Cancer: A Clinicopathologic and Molecular Study of 15 Surgical Cases. Yoshida A, Kohno T, Tsuta K, Wakai S, Arai Y, Shimada Y, Asamura H, Furuta K, Shibata T, Tsuda H. Am J Surg Pathol. 2013 Apr;37(4):554-62. doi : 10.1097/PAS.0b013e3182758fe6 PMID: 23426121

- Identification of ROS1 rearrangement in gastric adenocarcinoma. Lee J, Lee SE, Kang SY, Do IG, Lee S, Ha SY, Cho J, Kang WK, Jang J, Ou SH, Kim KM. Cancer. 2013 May 1;119(9):1627-35. doi : 10.1002/cncr.27967 PMID: 23400546