pulmonary atypical adenomatous hyperplasia
Tuesday 12 March 2013
Definition: Atypical adenomatous hjyperplasia (AAH) is defined in the WHO Histological Typing of Lung and Pleural Tumors 3rd Ed as follows,: "A focal lesion, often 5 mm or less in diameter, in which the involved alveoli and respiratory bronchioles are lined by monotonous, slightly atypical cuboidal to low columnar epithelial cells with dense nuclear chromatin, inconspicuous nucleoli and scant cytoplasm.
AAH is considered to be a precursor of pulmonary adenocarcinoma. It is usually an incidental finding in tumor resection specimens and is separate from the adenocarcinoma.
However, AAH changes may sometimes be encountered at the periphery of adenocarcinomas. In this case a tiny nodule of AAH was present at a distance from the adenocarcinoma.
AAH at Yale Rosen Collection
Invasive adenocarcinoma and atypical adenomatous hyperplasia at YRC
reactive atypical pneumocytic hyperplasia
non-mucinous bronchiolo-alveolar carcinoma
Atypical Adenomatous Hyperplasia of the Lung: A Probable Forerunner in the Development of Adenocarcinoma of the Lung. Masuko Mori et al. Mod Pathol 2001;14(2):72–84. http://www.nature.com/modpathol/journal/v14/n2/full/3880259a.html
DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. Selamat SA, Galler JS, Joshi AD, Fyfe MN, Campan M, Siegmund KD, Kerr KM, Laird-Offringa IA. PLoS One. 2011;6(6):e21443. doi : 10.1371/journal.pone.0021443 PMID: 21731750 [Free]
Cytogenetic findings in lung cancer that illuminate its biological history from adenomatous hyperplasia to bronchioalveolar carcinoma to adenocarcinoma: A case report. Bettio D, Cariboni U, Venci A, Valente M, Spaggiari P, Alloisio M. Exp Ther Med. 2012 Dec;4(6):1032-1034. PMID: 23226769
DNA methylation profile during multistage progression of pulmonary adenocarcinomas. Chung JH, Lee HJ, Kim BH, Cho NY, Kang GH. Virchows Arch. 2011 Aug;459(2):201-11. doi : 10.1007/s00428-011-1079-9 PMID: 21494759