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CST6

Sunday 10 March 2013

Pathology

- Detection of CST6 promoter methylation in primary breast tumors can provide important prognostic information in patients with operable breast cancer.
- CST6 promoter is also methylated in Circulating Tumor Cells (CTC).
- CST6 promoter is highly methylated in cfDNA of breast cancer patients, but not in healthy individuals. (#23006792#)
- CST6 promoter methylation in cfDNA, should be prospectively validated as a novel plasma tumor biomarker for breast cancer in a large cohort of breast cancer patients.

References

- CST6 promoter methylation in circulating cell-free DNA of breast cancer patients. Chimonidou M, Tzitzira A, Strati A, Sotiropoulou G, Sfikas C, Malamos N, Georgoulias V, Lianidou E. Clin Biochem. 2013 Feb;46(3):235-40. doi: 10.1016/j.clinbiochem.2012.09.015 . PMID: #23006792#