Wednesday 27 February 2013
Sarcoid Lung Disease
Granulomas of classic sarcoidosis are well formed, interstitial, surrounded by dense fibrosis. pic: movat pentachrome
End-stage pulmonary sarcoidosis
Sarcoid lung disease may result in progressive lung failure, necessitating transplant. There is a debate on whether the scarring is similar to or distinct from that seen in other fibrotic lung disease such as usual interstitial pneumonia (UIP).
In contrast to the honeycombing of UIP, the honeycombing was predominantly central, with prominent bronchiectasis.
The end-stage sarcoid lungs are characterized by a fibrotic and active granulomatous pattern, both of which are very distinct from that seen in UIP.
End-stage Sarcoid Lung Disease Is Distinct From Usual Interstitial Pneumonia. Xu L, Kligerman S, Burke A. Am J Surg Pathol. 2013 Feb 15. PMID: 23426125