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IgG4-associated pleural disease

Friday 4 January 2013

IgG4-related lung and pleural disease

Pleura is severely thickened by diffuse sclerosing inflammation.

Fibrosis is more pronounced on the side of the pleural cavity.

In the parietal lesion, sclerosing inflammation extends into subpleural fibrous and adipose tissue.

Visceral pleural lesions severely involve subpleural lung parenchyma.

Those parenchymal lesions resembled the solid nodular type.

References

- Pulmonary manifestations of immunoglobulin G4-related sclerosing disease. Ryu JH, Sekiguchi H, Yi ES. Eur Respir J. 2012 Jan;39(1):180-6. doi : 10.1183/09031936.00025211 PMID: 21719489

- IgG4-related lung and pleural disease: a clinicopathologic study of 21 cases. Zen Y, Inoue D, Kitao A, Onodera M, Abo H, Miyayama S, Gabata T, Matsui O, Nakanuma Y. Am J Surg Pathol. 2009 Dec;33(12):1886-93. doi : 10.1097/PAS.0b013e3181bd535b PMID: 19898222

- Lung involvement in IgG4-related lymphoplasmacytic vasculitis and interstitial fibrosis: report of 3 cases and review of the literature. Yamashita K, Haga H, Kobashi Y, Miyagawa-Hayashino A, Yoshizawa A, Manabe T. Am J Surg Pathol. 2008 Nov;32(11):1620-6. doi : 10.1097/PAS.0b013e318172622f PMID: 18753944