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lactating adenoma

Thursday 3 January 2013

Definition: Lactating adenoma is a focus of hyperplasia seen in breasts during pregnancy or puerperial period.

Images

- http://webpathology.com/case.asp?case=278

Macroscopy

Lactating adenoma may be solitary or multiple and has a gray cut surface.

Microscopy

- enlarged lobules containing markedly increased number of glands.
- greatly expanded lobules consisting of variably-sized glands.
- apical cytoplasmic blebs and fraying of the luminal border.
- The lobules are lined by actively secreting epithelial cells with vacuolated cytoplasm.
- Secretions may accumulate in the glands.
- The cells have basophilic cytoplasm, hyperchromatic nuclei with prominent nucleoli, and inconspicuous myoepithelial cell layer.