Sunday 30 December 2012
- Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors.
- Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes.
- Some results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and primary melanoma tissues and cells.
- It suggests a possible role of HOX C13 in metastatic melanoma switch.
Increased HOX C13 expression in metastatic melanoma progression. Cantile M, Scognamiglio G, Anniciello A, Farina M, Gentilcore G, Santonastaso C, Fulciniti F, Cillo C, Franco R, Ascierto PA, Botti G. J Transl Med. 2012 May 14;10:91. PMID: 22583695 [Free]