Home > G. Tumoral pathology > mature B-cell lymphomas

mature B-cell lymphomas

Friday 28 December 2012

mature B-cell neoplasms; mature B-cell tumors

Digital slides

- HPC:286 : Nodal mantle cell lymphoma
- HPC:294 - Small B cell lymphoma. Non otherwise specified - NOS
- HPC:296 : Colonic MALT lymphoma
- HPC:297 : gastric diffuse large B-cell lymphoma (mucosal biopsies)
- HPC:299 : Marginal zone B-cell lymphoma of the spleen
- HPC:301 : Mantle cell lymphoma of the ocular conjunctiva
- HPC:302 : Mediastinal-pulmonary diffuse large B-cell lymphoma (DLBCL), EBV-associated
- HPC:304 : gastric MALT lymphoma / gastric marginal zone lymphoma (mucosal biopsies)
- HPC:305 : diffuse large B-cell lymphoma of the tonsil (DLBCL of the tonsil)
- HPC:310 : thyroid follicular lymphoma
- HPC:342 (HPC:135) - Burkitt lymphoma (Mesentere)
- HPC:349 : Mediastinal sclerosing diffuse large B-cell lymphoma
- HPC:352 : Nodular lymphocyte predominant Hodgkin lymphoma

B-cell lymphomas

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.

Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.

WHO classification 2008 of B-cell neoplasms)

- mature B-cell neoplasms

  • chronic lymphocytic leukemia/small lymphocytic lymphoma
  • B-cell prolymphocytic leukemia
  • splenic marginal zone B-cell lymphoma (SMZBCL)
  • hairy cell leukemia
  • splenic B-cell lymphoma/leukemia, unclassifiable
    • splenic diffuse red pulp small B-cell lymphoma
    • hairy cell leukemia-variant
  • lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia)
  • heavy chain diseases
    • gamma heavy chain disease
    • mu heavy chain disease
    • alpha heavy chain disease
  • extranodal marginal zone B-cell lymphoma odf mucoasa-associated lymphoid tissue (extranodal MZBCL) (MALT lymphoma)
  • nodal marginal zone B-cell lymphoma (nodal MZBCL)
  • follicular lymphoma (follicular B-cell lymphoma, follicle centre cell lymphoma)
  • primary cutaneous follicle centre cell lymphoma
  • mantle cell lymphoma
  • diffuse large B-cell lymphomas (DLBCL), not otherwise specified (NOS)
    • T cell/histiocyte rich large B-cell lymphoma
    • primary DLBCL of the CNS
    • primary cutaneous DLBCL, leg type
    • EBV positive DLBCL of the elderly
  • DLBCL associated with chronic inflammation
  • lymphomatoid granulomatosis
  • primary mediastinal (thymic) large B-cell lymphoma
  • intravascular large B-cell lymphoma
  • primary cutaneous DLBCL, leg type
  • ALK positive large B-cell lymphoma
  • plasmablastic lymphoma
  • large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
  • primary effusion lymphoma
  • Burkitt lymphoma
  • B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
  • B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Architectural type

- nodular B-cell lymphoma
- diffuse B-cell lymphoma

Cytological type

- small cell B-cell lymphoma
- medium cell B-cell lymphoma

  • Burkitt lymphoma

- large cell B-cell lymphoma

  • diffuse large B-cell lymphoma (diffuse DLBCL)

Localization

- nodal lymphomas
- extra-nodal lymphomas

  • cutaneous lymphomas
  • salivary lymphomas
  • digestive lymphomas
  • pulmonary lymphomas

Cytogenetics

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.

Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.

- 1q12-22 rearrangements (12378526)

  • Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.
  • Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.
  • Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.
  • 1q12-22 breaks
  • dup(1)(q12-21q32)
  • trp(1)(q12q32)

See also

- B precursor lymphoid neoplasms

  • B lymphoblastic leukemia/lymphoma NOS
  • B lymphoblastic leukemia/lymphoma with recurrent genetic anomalies

- Leukemias
- Lymphomas
- Hdgkin lymphoma

  • nodular lymphocyte-predominant Hodgkin lymphoma
  • classical Hodgkin lymphoma
    • nodular sclerosis classical Hodgkin lymphoma
    • lymphocyte-rich classical Hodgkin lymphoma
    • mixed cellularity classical Hodgkin lymphoma
    • lymphocyte-depleted classical Hodgkin lymphoma

Reviews

- Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer. 2005 Apr;5(4):251-262. PMID: 15803153

- Ramsay M. Gene expression profiling to predict lymphoma outcome. Trends Mol Med. 2002 Apr;8(4):159. PMID: 11927271

- Arber DA. Molecular diagnostic approach to non-Hodgkin’s lymphoma. J Mol Diagn. 2000 Nov;2(4):178-90. PMID: 11232108

- Staudt LM. Molecular diagnosis of the hematologic cancers.
N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484

- K├╝ppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: 15803153

- O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: 17934490

References

- Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS. Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer. 2002 Dec;35(4):318-28. PMID: 12378526