Home > G. Tumoral pathology > mature B-cell lymphomas
mature B-cell lymphomas
Friday 28 December 2012
mature B-cell neoplasms; mature B-cell tumors
Digital slides
HPC:286 : Nodal mantle cell lymphoma HPC:294 - Small B cell lymphoma. Non otherwise specified - NOS HPC:296 : Colonic MALT lymphoma HPC:297 : gastric diffuse large B-cell lymphoma (mucosal biopsies) HPC:299 : Marginal zone B-cell lymphoma of the spleen HPC:301 : Mantle cell lymphoma of the ocular conjunctiva HPC:302 : Mediastinal-pulmonary diffuse large B-cell lymphoma (DLBCL), EBV-associated HPC:304 : gastric MALT lymphoma / gastric marginal zone lymphoma (mucosal biopsies) HPC:305 : diffuse large B-cell lymphoma of the tonsil (DLBCL of the tonsil) HPC:310 : thyroid follicular lymphoma HPC:342 (HPC:135) - Burkitt lymphoma (Mesentere) HPC:349 : Mediastinal sclerosing diffuse large B-cell lymphoma HPC:352 : Nodular lymphocyte predominant Hodgkin lymphoma
B-cell lymphomas
Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.
Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.
WHO classification 2008 of B-cell neoplasms)
mature B-cell neoplasms
- chronic lymphocytic leukemia/small lymphocytic lymphoma
- B-cell prolymphocytic leukemia
- splenic marginal zone B-cell lymphoma (SMZBCL)
- hairy cell leukemia
- splenic B-cell lymphoma/leukemia, unclassifiable
- splenic diffuse red pulp small B-cell lymphoma
- hairy cell leukemia-variant
- lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia)
- heavy chain diseases
- gamma heavy chain disease
- mu heavy chain disease
- alpha heavy chain disease
- plasma cell neoplasms
- monoclonal gammapathy of undetermined significance (MGUS)
- plasma cell myeloma
- solitary plasmocytoma of bone
- extraosseous plasmocytoma
- monoclonal immunoglobulin deposition diseases
- extranodal marginal zone B-cell lymphoma odf mucoasa-associated lymphoid tissue (extranodal MZBCL) (MALT lymphoma)
- nodal marginal zone B-cell lymphoma (nodal MZBCL)
- follicular lymphoma (follicular B-cell lymphoma, follicle centre cell lymphoma)
- primary cutaneous follicle centre cell lymphoma
- mantle cell lymphoma
- diffuse large B-cell lymphomas (DLBCL), not otherwise specified (NOS)
- T cell/histiocyte rich large B-cell lymphoma
- primary DLBCL of the CNS
- primary cutaneous DLBCL, leg type
- EBV positive DLBCL of the elderly
- DLBCL associated with chronic inflammation
- lymphomatoid granulomatosis
- primary mediastinal (thymic) large B-cell lymphoma
- intravascular large B-cell lymphoma
- primary cutaneous DLBCL, leg type
- ALK positive large B-cell lymphoma
- plasmablastic lymphoma
- large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
- primary effusion lymphoma
- Burkitt lymphoma
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
- B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
Architectural type
nodular B-cell lymphoma diffuse B-cell lymphoma
Cytological type
small cell B-cell lymphoma medium cell B-cell lymphoma
- Burkitt lymphoma
large cell B-cell lymphoma
- diffuse large B-cell lymphoma (diffuse DLBCL)
Localization
nodal lymphomas extra-nodal lymphomas
- cutaneous lymphomas
- salivary lymphomas
- digestive lymphomas
- pulmonary lymphomas
Cytogenetics
Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.
Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.
1q12-22 rearrangements (#12378526#)
- Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.
- Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.
- Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.
- 1q12-22 breaks
- dup(1)(q12-21q32)
- trp(1)(q12q32)
See also
B precursor lymphoid neoplasms
- B lymphoblastic leukemia/lymphoma NOS
- B lymphoblastic leukemia/lymphoma with recurrent genetic anomalies
Leukemias Lymphomas Hdgkin lymphoma
- nodular lymphocyte-predominant Hodgkin lymphoma
- classical Hodgkin lymphoma
- nodular sclerosis classical Hodgkin lymphoma
- lymphocyte-rich classical Hodgkin lymphoma
- mixed cellularity classical Hodgkin lymphoma
- lymphocyte-depleted classical Hodgkin lymphoma
Reviews
Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer. 2005 Apr;5(4):251-262. PMID: #15803153#
Ramsay M. Gene expression profiling to predict lymphoma outcome. Trends Mol Med. 2002 Apr;8(4):159. PMID: #11927271#
Arber DA. Molecular diagnostic approach to non-Hodgkin’s lymphoma. J Mol Diagn. 2000 Nov;2(4):178-90. PMID: #11232108#
Staudt LM. Molecular diagnosis of the hematologic cancers.
N Engl J Med. 2003 May 1;348(18):1777-85. PMID: #12724484#
Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: #15803153#
O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: #17934490#
References
Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS. Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer. 2002 Dec;35(4):318-28. PMID: #12378526#
