mature B-cell lymphomas

Digital slides

 HPC:286 : Nodal mantle cell lymphoma
 HPC:294 - Small B cell lymphoma. Non otherwise specified - NOS
 HPC:296 : Colonic MALT lymphoma
 HPC:297 : gastric diffuse large B-cell lymphoma (mucosal biopsies)
 HPC:299 : Marginal zone B-cell lymphoma of the spleen
 HPC:301 : Mantle cell lymphoma of the ocular conjunctiva
 HPC:302 : Mediastinal-pulmonary diffuse large B-cell lymphoma (DLBCL), EBV-associated
 HPC:304 : gastric MALT lymphoma / gastric marginal zone lymphoma (mucosal biopsies)
 HPC:305 : diffuse large B-cell lymphoma of the tonsil (DLBCL of the tonsil)
 HPC:310 : thyroid follicular lymphoma
 HPC:342 (HPC:135) - Burkitt lymphoma (Mesentere)
 HPC:349 : Mediastinal sclerosing diffuse large B-cell lymphoma
 HPC:352 : Nodular lymphocyte predominant Hodgkin lymphoma

B-cell lymphomas

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.

Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.

WHO classification 2008 of B-cell neoplasms)

 mature B-cell neoplasms

• chronic lymphocytic leukemia/small lymphocytic lymphoma
• B-cell prolymphocytic leukemia
• splenic marginal zone B-cell lymphoma (SMZBCL)
• hairy cell leukemia
• splenic B-cell lymphoma/leukemia, unclassifiable
  • splenic diffuse red pulp small B-cell lymphoma
  • hairy cell leukemia-variant

• lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia)
• heavy chain diseases
  • gamma heavy chain disease
  • mu heavy chain disease
  • alpha heavy chain disease

• plasma cell neoplasms
  • monoclonal gammapathy of undetermined significance (MGUS)
  • plasma cell myeloma
  • solitary plasmocytoma of bone
  • extraosseous plasmocytoma
  • monoclonal immunoglobulin deposition diseases

• extranodal marginal zone B-cell lymphoma odf mucoasa-associated lymphoid tissue (extranodal MZBCL) (MALT lymphoma)
• nodal marginal zone B-cell lymphoma (nodal MZBCL)
• follicular lymphoma (follicular B-cell lymphoma, follicle centre cell lymphoma)
• primary cutaneous follicle centre cell lymphoma
• mantle cell lymphoma
• diffuse large B-cell lymphomas (DLBCL), not otherwise specified (NOS)
  • T cell/histiocyte rich large B-cell lymphoma
  • primary DLBCL of the CNS
  • primary cutaneous DLBCL, leg type
  • EBV positive DLBCL of the elderly

• DLBCL associated with chronic inflammation
• lymphomatoid granulomatosis
• primary mediastinal (thymic) large B-cell lymphoma
• intravascular large B-cell lymphoma
• primary cutaneous DLBCL, leg type
• ALK positive large B-cell lymphoma
• plasmablastic lymphoma
• large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
• primary effusion lymphoma
• Burkitt lymphoma
• B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
• B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Architectural type

 nodular B-cell lymphoma
 diffuse B-cell lymphoma

Cytological type

 small cell B-cell lymphoma
 medium cell B-cell lymphoma

• Burkitt lymphoma

 large cell B-cell lymphoma

• diffuse large B-cell lymphoma (diffuse DLBCL)

Localization

 nodal lymphomas
 extra-nodal lymphomas

• cutaneous lymphomas
• salivary lymphomas
• digestive lymphomas
• pulmonary lymphomas

Cytogenetics

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies.

Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis.

 1q12-22 rearrangements (12378526)

• Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.
• Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.
• Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.
• 1q12-22 breaks
• dup(1)(q12-21q32)
• trp(1)(q12q32)

See also

 B precursor lymphoid neoplasms

• B lymphoblastic leukemia/lymphoma NOS
• B lymphoblastic leukemia/lymphoma with recurrent genetic anomalies

 Leukemias
 Lymphomas
 Hdgkin lymphoma

• nodular lymphocyte-predominant Hodgkin lymphoma
• classical Hodgkin lymphoma
  • nodular sclerosis classical Hodgkin lymphoma
  • lymphocyte-rich classical Hodgkin lymphoma
  • mixed cellularity classical Hodgkin lymphoma
  • lymphocyte-depleted classical Hodgkin lymphoma

Reviews

 Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer. 2005 Apr;5(4):251-262. PMID: 15803153

 Ramsay M. Gene expression profiling to predict lymphoma outcome. Trends Mol Med. 2002 Apr;8(4):159. PMID: 11927271

 Arber DA. Molecular diagnostic approach to non-Hodgkin’s lymphoma. J Mol Diagn. 2000 Nov;2(4):178-90. PMID: 11232108

 Staudt LM. Molecular diagnosis of the hematologic cancers.
N Engl J Med. 2003 May 1;348(18):1777-85. PMID: 12724484

 Küppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-262. PMID: 15803153

 O’Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-6849. PMID: 17934490

References

 Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS. Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer. 2002 Dec;35(4):318-28. PMID: 12378526