DDR2

Discoidin domain receptor family, member 2, also known as DDR2 or CD167b (cluster of differentiation 167b), is a human gene.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism.

In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation.

This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction.

RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions.

This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.

Alternative splicing in the 5’ UTR results in multiple transcript variants encoding the same protein.

Pathology

 Mutations in the DDR2 kinase gene in pulmonary squamous cell carcinoma (#22328973#) [Free]

References

 Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Hammerman PS, Sos ML, Ramos AH et al. Cancer Discov. 2011 Jun;1(1):78-89. PMID: #22328973# [Free]