KRAS-G12S

Tumors

 KRAS-associated peripheral nerve sheath tumors

• KRAS-G12S-associated peripheral nerve sheath tumors (#23190154#).
• RAS pathway activation due to BRAF V600E and KRAS mutations is an important event in a subset of peripheral nerve sheath tumours not related to NF. (#23190154#)
• Benign (BPNST) and malignant (MPNST) peripheral nerve sheath tumours occur either sporadically or are related to neurofibromatosis (NF).
• The mechanisms involved are well known in NF-related tumours, but still remain unclear in sporadic cases.
• Somatic BRAF and KRAS mutations represent the most frequent genetic events in melanocytic neoplastic lesions.
• Because melanocytes and Schwann cells both derive from neural crest cells, BRAF and KRAS mutations might influence BPNST and MPNST development.

Reference

 BRAF V600E and KRAS G12S mutations in peripheral nerve sheath tumours. Serrano C, Simonetti S, Hernández-Losa J, Valverde C, Carrato C, Bagué S, Orellana R, Somoza R, Moliné T, Carles J, Huguet P, Romagosa C, Ramón Y Cajal S. Histopathology. 2012 Aug 31. PMID: #23190154#