Home > A. Molecular pathology > phospho-ERKTHR202/Tyr214

phospho-ERKTHR202/Tyr214

Monday 10 December 2012

Pathology

- hairy cell leukemia (HCL)

  • BRAF V600E mutations are present in virtually all cases of hairy cell leukemia (HCL). We hypothesized that detection of phospho-ERK (pERK) in tissue sections may be a useful marker for diagnosis of HCL.
  • The sensitivity and specificity of pERK for diagnosis of HCL is about 100%.
  • The presence of pERK as detected by immunohistochemical staining is a useful surrogate marker for BRAF V600E in the diagnosis of HCL.

References

- Phospho-ERKTHR202/Tyr214 Is Overexpressed in Hairy Cell Leukemia and Is a Useful Diagnostic Marker in Bone Marrow Trephine Sections. Warden DW, Ondrejka S, Lin J, Durkin L, Bodo J, Hsi ED. Am J Surg Pathol. 2012 Dec 1. PMID: 23211289