phospho-ERKTHR202/Tyr214

Pathology

 hairy cell leukemia (HCL)

• BRAF V600E mutations are present in virtually all cases of hairy cell leukemia (HCL). We hypothesized that detection of phospho-ERK (pERK) in tissue sections may be a useful marker for diagnosis of HCL.
• The sensitivity and specificity of pERK for diagnosis of HCL is about 100%.
• The presence of pERK as detected by immunohistochemical staining is a useful surrogate marker for BRAF V600E in the diagnosis of HCL.

References

 Phospho-ERKTHR202/Tyr214 Is Overexpressed in Hairy Cell Leukemia and Is a Useful Diagnostic Marker in Bone Marrow Trephine Sections. Warden DW, Ondrejka S, Lin J, Durkin L, Bodo J, Hsi ED. Am J Surg Pathol. 2012 Dec 1. PMID: #23211289#