Home > A. Molecular pathology > Targeted therapy > Small molecules > ponatinib

ponatinib

Thursday 29 November 2012

WKP

Ponatinib (AP24534) is an experimental oral drug candidate for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor.

Some forms of CML, those that have the T315I mutation, are resistant to current therapies such as imatinib. Ponatinib has been designed to be effective against these types of tumors.