Home > A. Molecular pathology > Immunochemistry > cytokeratin 5/6

cytokeratin 5/6

Wednesday 26 September 2012

Pathology

All squamous carcinomas of the lung express cytokeratin 5/6.

Cytokeratin 5/6 reactivity was observed in all 40 mesotheliomas, but there was none in any of the 30 pulmonary adenocarcinomas.

The cytokeratin 5/6 immunostaining is useful in separating epithelial pleural mesotheliomas from pulmonary adenocarcinomas but also can assist in distinguishing epithelial mesotheliomas from nonpulmonary adenocarcinomas metastatic to the pleura.

Reference

- Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Ordóñez NG. Am J Surg Pathol. 1998 Oct;22(10):1215-21. PMID: #9777983#