lichenoid actinic keratosis
Tuesday 25 September 2012
Lichenoid actinic keratosis will show some degree of interface change with associated lymphocytic infiltrate within the superficial dermis.
Changes of lichen simplex chronicus accompany many atypical squamoproliferative lesions, such as hypertrophic actinic keratosis and squamous cell carcinoma.
Beware of a superficially sampled lesion, especially on sites such as the dorsal hand or forearm.
In lichenoid actinic keratoses there is a superficial, often band-like, chronic inflammatory cell infiltrate, with occasional apoptotic keratinocytes in the basal layer and some basal vacuolar change.
The acral keratotic lesions with a lichenoid infiltrate, reported as a possible manifestation of graft-versus-host disease, may have been a manifestation of HPV infection, as wart-virus features sometimes remit in the presence of a lichenoid infiltrate.