lichenoid actinic keratosis
Tuesday 25 September 2012
Changes of lichen simplex chronicus accompany many atypical squamoproliferative lesions, such as hypertrophic actinic keratosis and squamous cell carcinoma.
Beware of a superficially sampled lesion, especially on sites such as the dorsal hand or forearm.
In lichenoid actinic keratoses there is a superficial, often band-like, chronic inflammatory cell infiltrate, with occasional apoptotic keratinocytes in the basal layer and some basal vacuolar change.
The acral keratotic lesions with a lichenoid infiltrate, reported as a possible manifestation of graft-versus-host disease, may have been a manifestation of HPV infection, as wart-virus features sometimes remit in the presence of a lichenoid infiltrate.