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prostatic atypical basal cell hyperplasia

Thursday 30 August 2012

prostate atypical basal cell hyperplasia

Atypical adenomatous hyperplasia (adenosis) - when seen in a needle biopsy - is one of the most challenging benign mimics of cancer.

Synopsis

- In rare instances, basal cell hyperplasia shows prominent nucleoli. This is referred to as atypical basal cell hyperplasia. In most cases, this is in response to inflammation nearby.
- The immunostain for high molecular weight cytokeratin 34bE12 nicely demonstrates the fragmented basal cell layer in this focus of AAH encountered in a needle biopsy.
- The immunostain for high molecular weight cytokeratin 34bE12 demonstrates fragmented basal cell layer in the previous focus of AAH.
- However, there is a lack of cytologic atypia in AAH at high magnification.

Differential diagnosis

A partially sampled focus of cancer may be mistaken for AAH.

Links

- WebPathology

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