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thoracic liposarcoma

Monday 27 August 2012

Liposarcomas of the mediastinum and thorax

Liposarcoma rarely occurs in the thiorax.

The mediastinum shows a preponderance of uncommon subtypes and unusual morphologic variants.

Correct classification has important implications, with most patients with well-differentiated/dedifferentiated liposarcoma having a protracted clinical course, in contrast to the more rapid disease progression seen in patients with myxoid and pleomorphic liposarcoma.


- well-differentiated liposarcoma
- dedifferentiated liposarcoma
- pleomorphic liposarcomas (CPM- or DDIT3-)
- myxoid liposarcoma
- unclassifiable liposarcoma (CPM- and DDIT3-)
- unusual subtypes

  • myxoid well-differentiated liposarcoma
  • lipoleiomyosarcoma
  • dedifferentiated liposarcoma with "meningothelial"-like dedifferentiation
  • differentiated myxoid liposarcoma mimicking well-differentiated liposarcoma (CPM-)
  • pleomorphic liposarcoma with epithelioid and myxoid change.


- Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features. Boland JM, Colby TV, Folpe AL. Am J Surg Pathol. 2012 Sep;36(9):1395-403. PMID: 22895273