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Paget disease of the nipple
Sunday 29 November 2015
Paget’s disease of the nipple; Paget disease of the breast
Images
Paget disease of the breast. DCIS associated in the breast. Ddx: CIS/Bowen : K5/6+ ; Melanoma IS : MelanA
Microscopy
Paget’s cells have pale, vacuolated cytoplasm and large nuclei and migrate through the epidermis from parabasal cell layers upward.
highest concentration in the deep layers of epidermis.
Hyperkeratosis of epidermis and chronic inflammation in the dermis are common.
Paget’s cells permeate through the epidermis.
Immunochemistry
About half of cases of Paget’s disease are positive for mucicarmin.
Paget’s disease is positive for LMWCKs .
Half of case of Paget’s disease are positive for GCDFP .
Paget’s disease is positive for Her2 .
Paget’s disease of the nipple is positive for LMWCK such as Cam5.2 and negative for HMWCK such as CK903 and CK5/6 . It is also positive for CK7
See also
pagetoid appearance
