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sclerosing mucoepidermoid carcinoma.

Tuesday 14 August 2012

Sclerosing Variant of Mucoepidermoid Carcinoma.

Definition: Mucoepidermoid carcinoma (MEC) is the most common primary malignancy in the salivary gland. The rare sclerosing variant of MEC is characterized by dense stromal sclerosis and lymphoplasmacytic infiltrates.

IgG4+ Plasma Cells in Sclerosing Variant of Mucoepidermoid Carcinoma

- IgG4-related sclerosing disease is a recently described syndrome with unique histologic features characterized by intense lymphoplasmacytic infiltrates with increased IgG4 plasma cells and dense stromal sclerosis.
- The disease spectrum frequently includes benign inflammatory diseases, such as autoimmune pancreatitis, cholangitis, and chronic sclerosing sialadenitis (CSS).
- An increased IgG4 plasma cells in sclerosing MEC has been demonstrated. (22743285)
- The association of elevated IgG4 plasma cells with increased fibrosis in the sclerosing variant of MEC suggests a role of IgG4 plasma cells in fibrogenesis and may be a new concept related to sclerosis in cancer.


- IgG4+ Plasma Cells in Sclerosing Variant of Mucoepidermoid Carcinoma. Tian W, Yakirevich E, Matoso A, Gnepp DR. Am J Surg Pathol. 2012 Jul;36(7):973-9. PMID: 22743285