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CRX

info HGNC:2383

Friday 10 August 2012

cone-rod homeobox; CRD, LCA7, "orthodenticle homeobox 3", OTX3; CORD2

The cone-rod homeobox-containing gene (CRX) is a transcription factor that is preferentially expressed in retinal photoreceptor cells.

The CRX antibody is a good immunohistochemical marker to differentiate retinoblastoma from other intracranial MSRCTs.

CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, MSRCTs of childhood.

Reference

- Immunohistochemical Expression of CRX in Extracranial Malignant Small Round Cell Tumors. Terry J, Calicchio ML, Rodriguez-Galindo C, Perez-Atayde AR. Am J Surg Pathol. 2012 Aug;36(8):1165-9. PMID: #22790857#