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ERG/P63 double immunohistochemical staining

Thursday 2 August 2012

TMPRSS2:ERG gene rearrangement was found to be highly specific for and detected in approximately 50% of prostate cancer.

The P63/ERG double immunostain combines the high sensitivity of P63 and the high specificity of ERG and may be potentially useful in the work-up of difficult prostate biopsies. (#21623182#)

The high specificity of ERG for the presence of cancer may have important implications for prostate biopsy interpretation and needs to be further validated in larger prospective studies. (#21623182#)

References

- The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies. Yaskiv O, Zhang X, Simmerman K, Daly T, He H, Falzarano S, Chen L, Magi-Galluzzi C, Zhou M. Am J Surg Pathol. 2011 Jul;35(7):1062-8. PMID: #21623182#