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immunophenotype of mature B-cell lymphomas

Friday 10 August 2012

- small lymphocytic lymphoma

  • strong expression: IgM/IgD, CD20, CD22, CD5, CD19, CD79a, CD23, CD43
  • weak expression: CD11c
  • negative: CD10
  • usually negative: FMC7, CD79b, CyD1
  • possible atypical immunophenotype: CD5-, CD23-, FMC7+, CD11c+

- B-cell prolymphocytic leukemia

  • strong expression: IgM+/IgD+, CD19, CD20, CD22, CD79a, CD79b, FMC7
  • possible expression: CD5 (20-30%), CD23 (10-20%), ZAP-70 (57%), CD38 (46%)

- splenic marginal zone lymphoma

  • strong expression: sIgM, CD20, CD79a,
  • possible expression: IgD
  • usually negative: CD5
  • negative: CD5, CD10, BCL6, CD23, CD43, annexin A1, CyD1

- hairy cell leukemia

  • strong expression: CD20, CD22, CD11c
  • expression: CD103, CD25, CD123, T-bet, Annexin A1 (ANXA1), DBA 44 (CD72), FMC-7 and CyD1
  • usuallly negative: CD5 and CD10