vacuoles in acinar adenocarcinoma of the prostate
Tuesday 31 July 2012, by
Whereas vacuoles in adenocarcinoma of the prostate are not uncommon, true mucin-positive signet-ring cell carcinomas of prostate are exceedingly rare with only a handful of bona fide cases reported in the literature.
Vacuoles may distort the architecture and it is controversial as to what grade should be assigned.
Gleason’s only mention of vacuoles described them as signet cells under pattern 5 tumor.
The consensus was that tumors should be graded, as if the vacuoles were not present, by only evaluating the underlying architectural pattern.