Home > D. Systemic pathology > Vascular anomalies > atherosclerosis

atherosclerosis

Saturday 22 November 2003

WKP

Digital slides

- UI:254 - Atherosclerosis - recanalization
- UI:390 - Atherosclerosis with fatty streak
- UI:614 - Atherosclerosis: Cholesterol clefts
- UI:677 - Atherosclerosis: Cholesterol clefts and dystrophic calcifiction
- UI:716: Thrombus on Atherosclerotic plaque

Definition: Atherosclerosis is a ’narrowing’ or hardening of the arteries by fibrosis of the vascular wall caused by atheroma.

Itis a pathological process that involves the progressive expansion of lesions (plaques) that reduce blood flow in arteries.

Atherosclerosis is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol.

It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophage white blood cells and promoted by low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high-density lipoproteins (HDL), (see apoA-1 Milano).

It is commonly referred to as a hardening or furring of the arteries. It is caused by the formation of multiple plaques within the arteries.

See also

- arteriosclerosis (also known as arteriosclerotic vascular disease or ASVD)

References

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- Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005 Apr 21;352(16):1685-95. PMID: #15843671#

- Xu Q. Mouse models of arteriosclerosis: from arterial injuries to vascular grafts. Am J Pathol. 2004 Jul;165(1):1-10. PMID: #15215157#

- Scott J. Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004 Jun;14(3):271-9. PMID: #15172670#

- Boisvert WA. Modulation of atherogenesis by chemokines. Trends Cardiovasc Med. 2004 May;14(4):161-5. PMID: #15177267#

- Kutuk O, Basaga H. Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med. 2003 Dec;9(12):549-57. PMID: #14659470#

- de Nigris F, Lerman A, Ignarro LJ, Williams-Ignarro S, Sica V, Baker AH, Lerman LO, Geng YJ, Napoli C. Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends Mol Med. 2003 Aug;9(8):351-9. PMID: #12928037#

- Albertini R, Moratti R, De Luca G. Oxidation of low-density lipoprotein in atherosclerosis from basic biochemistry to clinical studies. Curr Mol Med. 2002 Sep;2(6):579-92. PMID: #12243250#

- Duval C, Chinetti G, Trottein F, Fruchart JC, Staels B. The role of PPARs in atherosclerosis. Trends Mol Med. 2002 Sep;8(9):422-30. PMID: #12223313#

- Ursini F, Davies KJ, Maiorino M, Parasassi T, Sevanian A. Atherosclerosis: another protein misfolding disease? Trends Mol Med. 2002 Aug;8(8):370-4. PMID: #12127722#

- Boerwinkle E, Ellsworth DL, Hallman DM, Biddinger A. Genetic analysis of atherosclerosis: a research paradigm for the common chronic diseases. Hum Mol Genet. 1996;5 Spec No:1405-10. PMID: #8875244#