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prostatic large cell neuroendocrine carcinoma

Monday 13 August 2012

prostatic large-cell neuroendocrine carcinoma

Definition: Prostatic large cell neuroendocrine carcinoma is an extremely rare variant with histological features identical to those of large-cell carcinoma in the lung.

Among the rare cases thus far reported, most patients had a history of adenocarcinoma treated with hormonal therapy.

The mean age was 67 years (range 43–81 years). Microscopically, sections showed sheets and ribbons of cells with large nuclei with coarse chromatin and prominent nucleoli.

Mitotic activity and tumoral necrosis were prominent.

Admixed acinar adenocarcinoma was identified in most cases.

Positive immunostains include chromogranin, synaptophysin, CD56, CD57, and AMACR. Focal PSA and PSAP immunoreactivity was also noted. The prognosis is dismal: the mean survival was 7 months.


- Histological variants of prostatic carcinoma and their significance. Humphrey PA. Histopathology. 2012 Jan;60(1):59-74. PMID: 22212078