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prostatic clear cell adenocarcinoma

Thursday 8 December 2016

prostate clear cell adenocarcinoma


There are single case reports of renal-type clear cell carcinoma, tubulocystic clear cell adenocarcinoma of the prostate, and clear cell adenocarcinoma resembling Mullerian/urethral adenocarcinoma arising in the prostatic utricle.


- tubulocystic and papillary glands lined by glycogen-rich, cuboidal or hobnail cells with clear to eosinophilic cytoplasm
- enlarged nuclei with mild pleomorphism and prominent nucleoli
- may have prominent vasculature, inflammatory infiltrate, hyaline globules, psammoma bodies
- resembles ovarian neoplasm

Differential diagnosis

- urothelial carcinoma : clear cell variant
- renal cell carcinoma : metastatic; history of renal primary
- nephrogenic adenoma

  • tubules composed of single layer of cuboidal or flattened cells with clear to eosinophilic cytoplasm
  • round nuclei with fine chromatin


- Histological variants of prostatic carcinoma and their significance. Humphrey PA. Histopathology. 2012 Jan;60(1):59-74. PMID: 22212078