mammary metaplastic carcinoma
Sunday 8 July 2012
Metaplastic carcinoma of the breast, metaplastic breast carcinoma
Metaplastic breast carcinoma is a rare and aggressive histologic type of breast cancer, preferentially displaying a triple-negative phenotype.
The diversity of histologic features of metaplastic breast carcinomas is reflected at the transcriptomic level, and an association between molecular subtypes and histology was observed.
BRCA1-like genomic profiles are found only in a subset (31%) of metaplastic breast cancers, and are not associated with a specific molecular or histologic subtype.
Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity. Weigelt B, Ng CK, Shen R, Popova T, Schizas M, Natrajan R, Mariani O, Stern MH, Norton L, Vincent-Salomon A, Reis-Filho JS. Mod Pathol. 2015 Mar;28(3):340-51. doi : 10.1038/modpathol.2014.142 PMID: 25412848 (Free)