mammary metaplastic carcinoma
Sunday 8 July 2012
Metaplastic carcinoma of the breast, metaplastic breast carcinoma; Metaplastic carcinoma of the breast
Definition: Metaplastic breast carcinoma is a rare and aggressive histologic type of breast cancer, preferentially displaying a triple-negative phenotype.
Metaplastic carcinoma of the breast
Differential diagnosis: mammary biphasic lesions
- mammary juvenile fibroadenoma
p63 is sensitive and specific for metaplastic carcinoma.
Negative : ER-, PR-, HER2-, mammaglobin-
BRCA1-like genomic profiles are found only in a subset (31%) of metaplastic breast cancers, and are not associated with a specific molecular or histologic subtype.
Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity. Weigelt B, Ng CK, Shen R, Popova T, Schizas M, Natrajan R, Mariani O, Stern MH, Norton L, Vincent-Salomon A, Reis-Filho JS. Mod Pathol. 2015 Mar;28(3):340-51. doi : 10.1038/modpathol.2014.142 PMID: 25412848 (Free)