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mammary metaplastic carcinoma

Sunday 8 July 2012

Metaplastic carcinoma of the breast, metaplastic breast carcinoma; Metaplastic carcinoma of the breast

Definition: Metaplastic breast carcinoma is a rare and aggressive histologic type of breast cancer, preferentially displaying a triple-negative phenotype.

Images

- Metaplastic carcinoma of the breast

Digital cases

- JRC:5046 : Metaplastic carcinoma of the breast.
- JRC:5047 : Metaplastic carcinoma of the breast.
- JRC:5048 : Metaplastic carcinoma of the breast.

The diversity of histologic features of metaplastic breast carcinomas is reflected at the transcriptomic level, and an association between molecular subtypes and histology was observed.

Differential diagnosis: mammary biphasic lesions

- adenomyoepithelioma
- mammary fibroadenomas

- mammary hamartoma
- metaplastic mammary carcinoma
- phyllodes tumor
- pleomorphic adenoma
- gynecomastia
- pubertal macromastia

IHC

- p63 is sensitive and specific for metaplastic carcinoma.
- Negative : ER-, PR-, HER2-, mammaglobin-

Molecular biology

BRCA1-like genomic profiles are found only in a subset (31%) of metaplastic breast cancers, and are not associated with a specific molecular or histologic subtype.

See also

- mammary carcinomas

Open references

- Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity. Weigelt B, Ng CK, Shen R, Popova T, Schizas M, Natrajan R, Mariani O, Stern MH, Norton L, Vincent-Salomon A, Reis-Filho JS. Mod Pathol. 2015 Mar;28(3):340-51. doi : 10.1038/modpathol.2014.142 PMID: 25412848 (Free)