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mammary invasive micropapillary carcinoma

Thursday 5 July 2012

invasive micropapillary carcinoma of the breast

Definition: Invasive micropapillary carcinomas (IMPC) of the breast are aggressive tumors frequently associated with lymphatic invasion and nodal metastasis even when micropapillary (MP) differentiation is very focal within the tumors.

Images

- FNA of mammary invasive micropapillary carcinoma

- Invasive micropapillary carcinoma of the breast: inside-out pattern, EMA+, ER+, PR+(50%), HER2+(30%), Luminal A/B

See also

- mammary carcinomas

Images

- Invasive micropapillary carcinoma of the breast: inside-out pattern, EMA+, ER+, PR+(50%), HER2+(30%), Luminal A/B

- Invasive micropapillary carcinoma of the breast : reversed apical pattern of MUC1 expression

- FNA of mammary invasive micropapillary carcinoma

Some have noticed that some breast carcinomas showing lymphatic spread but lacking histologic features of IMPC have occasional tumor cell clusters reminiscent of those of IMPC without the characteristic prominent retraction artifact. (20975342)

The presence of both PRCP and MP features are strongly associated with decreased cytoplasmic EMA immunoreactivity and the presence of lymphatic invasion and nodal metastasis, even if such features were present only very focally. (20975342)

Breast carcinomas with PRCP may have the same implication as MP differentiation and these tumors may represent part of a spectrum of IMPC. Complete or partial reversal of cell polarity may play a significant role in lymphatic tumor spread. (20975342)

See also

- mammary micropapillary carcinoma
- micropapillary carcinomas / micropapillary tumors

Reference

- Invasive ductal carcinomas of the breast showing partial reversed cell polarity are associated with lymphatic tumor spread and may represent part of a spectrum of invasive micropapillary carcinoma. Acs G, Esposito NN, Rakosy Z, Laronga C, Zhang PJ. Am J Surg Pathol. 2010 Nov;34(11):1637-46. PMID: 20975342