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sclerosing adenosis

Wednesday 4 July 2012

sclerozing adenosis of the breast, mammary sclerosing adenosis; Fibrosclerosis of breast

PO WP

Definition: Sclerosing adenosis has sclerosis, increased glands and stromal growth compressing the glands; on low power it shows a lobulated outline and a myoepithelial layer.

Images

- Wikimedia: sclerosing adenosis of the breast.

- sclerosing adenosis and collagenous spherulosis

Digital cases

- JRC:5279 : sclerosing adenosis of the breast.
- JRC:5280 : sclerosing adenosis of the breast.
- JRC:5283 : sclerosing adenosis of the breast.
- JRC:5287 : sclerosing adenosis of the breast.

Microscopy

Sclerosing adenosis has a lobulated outline and a myoepithelial layer. It can be easiest to differentiate it from carcinoma on low power from its lobular outline.

- The enlarged lobule undergoes fibrosis.
- Multiple microcalcifications present as purple, round bodies.
- proliferation of myoepithelial cells and stromal fibrosis.
- Microcalcifications have a laminated, purple appearance.

- At late stage

  • acini begin to decrease in number.
  • Atrophic acini are surrounded by abundant fibrous stroma.

Differential diagnosis

Sclerosing adenosis has a lobulated outline and a myoepithelial layer.

See also

- breast diseases
- breast lesions

  • adenosis