proximal colon cancer
Monday 2 July 2012
Proximal colon cancers; proximal colic adenocarcinoma
The serrated neoplasia pathway is thought to give rise to the majority of sporadic microsatellite instability-high (MSI-H) colon cancer.
Histological analysis of the precursor adenomas to sporadic MSI-H colon cancer demonstrated a high frequency of crypt serrations compared with MSS colon cancer (93 vs 36%, P < 0.001).
BRAF mutations are found in 76% of sporadic MSI-H and 11% of MSS colon cancers (P < 0.001).
The presence of BRAF mutations in these adenomatous precursors suggests that they represent sessile serrated adenomas with complete cytologic dysplasia.
Patients with sporadic MSI-H colon cancer were more likely to harbour synchronous sessile serrated adenomas (20 vs 8%; P=0.023).
Proximal colon cancers and the serrated pathway: a systematic analysis of precursor histology and BRAF mutation status. Patil DT, Shadrach BL, Rybicki LA, Leach BH, Pai RK. Mod Pathol. 2012 Jun 8. PMID: 22684223