Monday 2 July 2012
HGAL, "human germinal center-associated lymphoma", MGC40441; info germinal center expressed transcript 2
diffuse large B-cell lymphoma (DLBCL)
- Diffuse large B-cell lymphomacan be subclassified into at least two molecular subgroups by gene expression profiling: germinal center B-cell like and activated B-cell like diffuse large B-cell lymphoma.
- Several immunohistological algorithms have been proposed as surrogates to gene expression profiling at the level of protein expression, but their reliability has been an issue of controversy.
- Furthermore, the proportion of misclassified cases of germinal center B-cell subgroup by immunohistochemistry, in all reported algorithms, is higher compared with germinal center B-cell cases defined by gene expression profiling.
- HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma.
The contribution of HGAL/GCET2 in immunohistological algorithms: a comparative study in 424 cases of nodal diffuse large B-cell lymphoma. Gualco G, Bacchi LM, Domeny-Duarte P, Natkunam Y, Bacchi CE. Mod Pathol. 2012 Jun 29. PMID: 22743653