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CD133+ prostate cells
Thursday 12 April 2012
Prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized.
CD133+ cells freshly isolated from benign prostate tissue exhibited an expression profile characteristic of a putative stem/progenitor cell population, with transcripts involved in biological processes ranging from development and ion homeostasis to cell communication.
The profile of CD133- cells is consistent with that of a transit amplifying population, suggesting up-regulated proliferation and metabolism.
Comparison of benign populations to those from HRPC showed some similarities between CD133+ profiles but also revealed significant differences that provide a tumor-specific pattern, which included evidence of increased metabolic activity and active proliferation.
Expression of some markers in prostate tumors has been found, including the oligodendrocyte lineage transcription factor OLIG1.
References
Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Shepherd CJ, Rizzo S, Ledaki I, Davies M, Brewer D, Attard G, de Bono J, Hudson DL. Prostate. 2008 Jun 15;68(9):1007-24. PMID: 18398820
