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thyroid papillary carcinoma, follicular variant

Saturday 7 April 2012

Papillary carcinoma of the thyroid, follicular variant

GFMER

Digital cases

- JRC:482 : Papillary carcinoma of the thyroid, partially follicular, with tall cell features.
- JRC:2666 : Thyroid Papillary carcinoma, encapsulated follicular variant (36 y/o male).
- JRC:3187 : Thyroid Papillary carcinoma, follicular and oncocytic variant (36 y/o male).
- JRC:3349 : Thyroid Papillary carcinoma, follicular variant.
- JRC:14915 : Papillary carcinoma, tall cell, predominantly follicular variant.
- JRC:15037 : Papillary carcinoma, follicular variant, encapsulated.
- JRC:18923 : Thyroid papillary carcinoma, follicular variant (Initailly called "Thyroid follicular carcinoma with extensive soft tissue invasion and with massive blood vessel invasion") (F, 76 y/o)
- JRC:18924 : Follicular carcinoma with limited invasion and with probable blood vessel invasion.

Molecular biology

The follicular variant of PTC (FV-PTC) shares some clinicopathologic and molecular features with both PTC and FTC.

A PAX8-PPARgamma fusion gene (associated with FTC) is observed more frequently than BRAF or RET-PTC alterations (associated with PTC).

Molecular heterogeneity, although an uncommon phenomenon, may occur in thyroid carcinoma and demonstrate the coexistence in a case of FV-PTC not only of the histologic but also of the molecular features of both PTC (RET-PTC) and FTC (PAX8-PPARgamma).

See also

- thyroid papillary carcinoma

References

- Simultaneous Occurrence of PAX8-PPARg and RET-PTC3 Rearrangements in a Follicular Variant of Papillary Thyroid Carcinoma. Caria P, Dettori T, Frau DV, Di Oto E, Morandi L, Parmeggiani A, Tallini G, Vanni R. Am J Surg Pathol. 2012 Sep;36(9):1415-20. PMID: 22895275