Home > E. Pathology by systems > Endocrine system > Thyroid > thyroid papillary carcinoma, follicular variant

thyroid papillary carcinoma, follicular variant

Saturday 7 April 2012

Papillary carcinoma of the thyroid, follicular variant; FVPTC, FV-PTC


Digital cases

- JRC:482 : Papillary carcinoma of the thyroid, partially follicular, with tall cell features.
- JRC:2666 : Thyroid Papillary carcinoma, encapsulated follicular variant (36 y/o male).
- JRC:3187 : Thyroid Papillary carcinoma, follicular and oncocytic variant (36 y/o male).
- JRC:3349 : Thyroid Papillary carcinoma, follicular variant.
- JRC:14915 : Papillary carcinoma, tall cell, predominantly follicular variant.
- JRC:15037 : Papillary carcinoma, follicular variant, encapsulated.
- JRC:18923 : Thyroid papillary carcinoma, follicular variant (Initailly called "Thyroid follicular carcinoma with extensive soft tissue invasion and with massive blood vessel invasion") (F, 76 y/o)
- JRC:18924 : Follicular carcinoma with limited invasion and with probable blood vessel invasion.


- encapsulated type (EFVPTC)

Molecular biology

The follicular variant of PTC (FV-PTC) shares some clinicopathologic and molecular features with both PTC and FTC.

A PAX8-PPARgamma fusion gene (associated with FTC) is observed more frequently than BRAF or RET-PTC alterations (associated with PTC).

Molecular heterogeneity, although an uncommon phenomenon, may occur in thyroid carcinoma and demonstrate the coexistence in a case of FV-PTC not only of the histologic but also of the molecular features of both PTC (RET-PTC) and FTC (PAX8-PPARgamma).

See also

- papillary thyroid carcinoma (PTC)

Open references

- Follicular variant of papillary thyroid cancer: encapsulated, nonencapsulated, and diffuse: distinct biologic and clinical entities. Gupta S, Ajise O, Dultz L, Wang B, Nonaka D, Ogilvie J, Heller KS, Patel KN. Arch Otolaryngol Head Neck Surg. 2012 Mar;138(3):227-33. doi : 10.1001/archoto.2011.1466 PMID: 22431868 (Free)


- Simultaneous Occurrence of PAX8-PPARg and RET-PTC3 Rearrangements in a Follicular Variant of Papillary Thyroid Carcinoma. Caria P, Dettori T, Frau DV, Di Oto E, Morandi L, Parmeggiani A, Tallini G, Vanni R. Am J Surg Pathol. 2012 Sep;36(9):1415-20. PMID: 22895275