pathway-targeted therapy of cancer
Monday 2 April 2012
Pathway-targeted therapeutics of cancer
Substantial recent progress has been reported in the context of implementing ’personalized’ cancer medicine, informed by tumor genotyping.
The recent FDA approvals of crizotinib, an ALK kinase inhibitor that has yielded significant clinical benefit in ALK-translocated lung cancers, and vemurafenib, a BRAF-selective kinase inhibitor that has demonstrated dramatic clinical efficacy in BRAF mutant melanoma patients, define the new landscape for tailored cancer drug therapy.
However, acquired drug resistance remains a significant obstacle to the long-term benefit of such treatments.
VEGF pathway-targeted therapy
PI3K pathway-targeted therapy (PI3K-targeted therapy)
MET pathway-targeted therapy
Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis. Yauch RL, Settleman J. Curr Opin Genet Dev. 2012 Feb;22(1):45-9. PMID: #22321987#